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Year Number of Results
2004 1
2005 4
2006 2
2007 3
2008 4
2009 2
2010 3
2011 2
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2013 4
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2015 3
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37 results

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Page 1
Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif.
Smith JL, Pathak VK. Smith JL, et al. J Virol. 2010 Dec;84(24):12599-608. doi: 10.1128/JVI.01437-10. Epub 2010 Oct 13. J Virol. 2010. PMID: 20943965 Free PMC article.
Human APOBEC3F (hA3F) and human APOBEC3G (hA3G) are potent anti-human immunodeficiency virus (anti-HIV) host factors that suppress viral replication by hypermutating the viral genome, inhibiting reverse transcription, and hindering integration. ...
Human APOBEC3F (hA3F) and human APOBEC3G (hA3G) are potent anti-human immunodeficiency virus (anti-HIV) host factors that suppress vi …
Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities.
Langlois MA, Beale RC, Conticello SG, Neuberger MS. Langlois MA, et al. Nucleic Acids Res. 2005 Apr 4;33(6):1913-23. doi: 10.1093/nar/gki343. Print 2005. Nucleic Acids Res. 2005. PMID: 15809227 Free PMC article.
We find that whereas APOBEC3C contains all the information necessary for both Vif-binding and cytidine deaminase activity in a single domain, it is the C-terminal domain of APOBEC3F and APOBEC3G that confer their target site specificity for cytidine deamination. We …
We find that whereas APOBEC3C contains all the information necessary for both Vif-binding and cytidine deaminase activity in a single …
APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.
Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR. Yu Q, et al. J Biol Chem. 2004 Dec 17;279(51):53379-86. doi: 10.1074/jbc.M408802200. Epub 2004 Oct 4. J Biol Chem. 2004. PMID: 15466872 Free article.
The lentiviral Vif protein prevents the deamination by inducing the degradation of APOBEC3G and APOBEC3F. We report here that two additional APOBEC3 family members, APOBEC3B and APOBEC3C, have potent antiviral activity against simian immuno-deficiency virus (SIV), b …
The lentiviral Vif protein prevents the deamination by inducing the degradation of APOBEC3G and APOBEC3F. We report here that two add …
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS. Hultquist JF, et al. J Virol. 2011 Nov;85(21):11220-34. doi: 10.1128/JVI.05238-11. Epub 2011 Aug 10. J Virol. 2011. PMID: 21835787 Free PMC article.
Furthermore, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H of the rhesus macaque also are packaged into and restrict Vif-deficient HIV-1 when stably expressed in T cells, and they are all neutralized by the simian immunodeficiency virus Vif protein. On the other hand, neither …
Furthermore, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H of the rhesus macaque also are packaged into and restrict Vif-deficient HIV-1 …
The APOBEC3C crystal structure and the interface for HIV-1 Vif binding.
Kitamura S, Ode H, Nakashima M, Imahashi M, Naganawa Y, Kurosawa T, Yokomaku Y, Yamane T, Watanabe N, Suzuki A, Sugiura W, Iwatani Y. Kitamura S, et al. Nat Struct Mol Biol. 2012 Oct;19(10):1005-10. doi: 10.1038/nsmb.2378. Epub 2012 Sep 23. Nat Struct Mol Biol. 2012. PMID: 23001005
To date, the structure of an A3 protein containing a Vif-binding interface has not been solved. Here, we report a high-resolution crystal structure of APOBEC3C and identify the HIV-1 Vif-interaction interface. Extensive structure-guided mutagenesis revealed the role of a s …
To date, the structure of an A3 protein containing a Vif-binding interface has not been solved. Here, we report a high-resolution crystal st …
Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases.
Siriwardena SU, Chen K, Bhagwat AS. Siriwardena SU, et al. Chem Rev. 2016 Oct 26;116(20):12688-12710. doi: 10.1021/acs.chemrev.6b00296. Epub 2016 Sep 1. Chem Rev. 2016. PMID: 27585283 Free PMC article. Review.
Members of the APOBEC3 subfamily in humans (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) inhibit infections of viruses such as HIV-1, HBV, and HCV, and retrotransposition of endogenous retroelements through mutagenic and nonmutagenic mec …
Members of the APOBEC3 subfamily in humans (APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H) inhibit …
Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I.
Yousefi M, Annan Sudarsan AK, Gaba A, Chelico L. Yousefi M, et al. Viruses. 2023 Feb 7;15(2):463. doi: 10.3390/v15020463. Viruses. 2023. PMID: 36851677 Free PMC article.
Here we determined if APOBEC3C, APOBEC3F, or APOBEC3G could hetero-oligomerize with APOBEC3H haplotype I. ...However, this increased APOBEC3F levels in cells and virions in the absence or presence of Vif and enabled APOBEC3F-mediated restriction of HIV …
Here we determined if APOBEC3C, APOBEC3F, or APOBEC3G could hetero-oligomerize with APOBEC3H haplotype I. ...However, this inc …
APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages.
Chaipan C, Smith JL, Hu WS, Pathak VK. Chaipan C, et al. J Virol. 2013 Jan;87(1):444-53. doi: 10.1128/JVI.00676-12. Epub 2012 Oct 24. J Virol. 2013. PMID: 23097438 Free PMC article.
We observed significant inhibition of HIV-1deltavif produced in 293T cells in the presence of APOBEC3DE (A3DE), APOBEC3F (A3F), APOBEC3G (A3G), and APOBEC3H haplotype II (A3H HapII) but not APOBEC3B (A3B), APOBEC3C (A3C), or APOBEC3H haplotype I (A3H HapI). ...
We observed significant inhibition of HIV-1deltavif produced in 293T cells in the presence of APOBEC3DE (A3DE), APOBEC3F (A3F), APOBE …
CagA increases DNA methylation and decreases PTEN expression in human gastric cancer.
Zhang B, Zhang X, Jin M, Hu L, Zang M, Qiu W, Wang S, Liu B, Liu S, Guo D. Zhang B, et al. Mol Med Rep. 2019 Jan;19(1):309-319. doi: 10.3892/mmr.2018.9654. Epub 2018 Nov 13. Mol Med Rep. 2019. PMID: 30431097 Free PMC article.
The expression levels of PTEN, Tet1, apolipoprotein B mRNA editing enzyme catalytic subunit (APOBEC)3A, APOBEC3C and APOBEC3F were significantly decreased in the CagA overexpression group compared with in the negative control group in HGC-27 cells. ...In conclusion, …
The expression levels of PTEN, Tet1, apolipoprotein B mRNA editing enzyme catalytic subunit (APOBEC)3A, APOBEC3C and APOBEC3F …
Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.
Bohn MF, Shandilya SM, Albin JS, Kouno T, Anderson BD, McDougle RM, Carpenter MA, Rathore A, Evans L, Davis AN, Zhang J, Lu Y, Somasundaran M, Matsuo H, Harris RS, Schiffer CA. Bohn MF, et al. Structure. 2013 Jun 4;21(6):1042-50. doi: 10.1016/j.str.2013.04.010. Epub 2013 May 16. Structure. 2013. PMID: 23685212 Free PMC article.
Human APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In this study the crystal structure of the HIV Vif binding, catalytically active, C-terminal domain of APOBEC3F (A3F-CTD) was determined. T …
Human APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In thi …
37 results